N-Iodosuccinimide

Product Details

CasNo： 516-12-1

MF： C4H4INO2

Appearance： Powder

Delivery Time： 15 days

Packing： 25kg/Drum

Purity： 99%

• Basic Information
  • Molecular Formula: C4H4INO2
  • Molecular Weight: 224.98
  • CAS Number: 516 - 12 - 1
  • Chinese Aliases: N-iodosuccinimide, N-iodobutanediimide, etc.
  • English Aliases: 1-iodo-2,5-pyrrolidinedione, NIS, etc.
• Physical Properties
  • Appearance: White to off - white powder or white acicular crystals.
  • Melting Point: 202 - 206 °C
  • Density: 2.3±0.1 g/cm³
  • Boiling Point: 249.6±23.0 °C at 760 mmHg
  • Solubility: Soluble in acetone, methanol, and dioxane. Slightly soluble in dichloromethane, and almost insoluble in carbon tetrachloride and diethyl ether. It decomposes in water.
• Chemical Properties: It has poor stability and is sensitive to moisture, light, and oxygen. It will decompose when exposed to water and is prone to photolysis under light. It should be kept away from oxidants, acids, and reducing agents.
• Applications
  • Organic Synthesis: It is a commonly - used iodination reagent, which can be used for the iodination of aldehydes and ketones, and is widely used in the iodination reactions of olefins, alkynes, and aromatic rings to prepare various organic compounds.
  • Oxidation Reaction: Reacting with oxidants can generate trivalent iodine intermediates to achieve substrate oxidation. It can also be used to prepare β - lactam antibiotics by oxidizing and cyclizing dipeptide molecules.
  • Pharmaceutical Intermediate: It is mainly used as a pharmaceutical intermediate in biopharmaceuticals, especially in the development of antibacterial (such as oseltamivir intermediate) and anti - tumor drugs (such as imatinib precursor modification). It can also be used for radioactive labeling, iodination functionalization of photosensitive drugs, and modification of carbohydrate drugs.
  • Others: It can also be used as an oxidation - titration reagent for sulfur and a catalyst for thioglycosides.
• Production Method: Usually, under light - proof conditions, succinimide is first reacted with silver oxide to prepare silver N - succinimide, which is then reacted with iodine in dry dioxane to generate N - iodosuccinimide.
• Storage Conditions: Store at 2 - 8 °C in a cool, dry, and well - ventilated warehouse. Keep away from fire sources and heat sources, and prevent direct sunlight. The packaging should be sealed, and it should be stored separately from acids and food chemicals.