English Name: N-Chlorosuccinimide, abbreviated as NCS.
Chinese Name: N-Chlorosuccinimide, also known as Succinyl Chlorimide.
CAS No.: 128 - 09 - 6.
Molecular Formula: C4H4ClNO2.
Molecular Weight: 133.53.
Physicochemical Properties
Appearance: Usually white crystalline powder or crystals.
Odor: With a chlorine - like odor.
Melting Point: 148 - 150°C (lit.).
Density: 1.65g/cm³.
Bulk Density: 600kg/m³.
Refractive Index: 1.4378 (estimate).
Flash Point: >110°C.
Solubility: Soluble in water, alcohols, benzene, acetone and acetic acid, slightly soluble in ether, chloroform, carbon tetrachloride and petroleum ether.
Acidity Coefficient: pKa -2.78±0.20 (Predicted).
Applications
Organic Synthesis Chlorinating Agent: It is an important chlorinating agent in organic synthesis, which can specifically substitute the α-H of fatty acyl chlorides to obtain high - purity α-chloro fatty acid and its derivatives. These derivatives are important raw materials in the fields of medicine, pesticides, spices, etc.
Pharmaceutical Intermediate: It can be used in the production of antibiotics, such as the synthesis of Cefaloram.
Oxidizing Agent: It can be used as an oxidizing agent. For example, in a two - phase system with the presence of tetrabutylammonium chloride, it can selectively oxidize primary alcohols to aldehydes through the catalysis of 2,2,6,6 - tetramethyl - 1 - piperidinyloxy (TEMPO).
Identification Reagent: It can be used to identify primary, secondary and tertiary alcohols.
Surface Treatment Agent: It is used as a surface treatment agent for polyester fibers, which can enhance their acceptance of dyes, adhesives and printing inks.
Safety Information
Hazardous Symbols: C (Corrosive), Xi (Irritant).
Risk Codes: 22 - 34, indicating that it is harmful if swallowed and may cause burns on contact with skin.
Safety Instructions: 26 - 36/37/39 - 45 - 37/39, that is, in case of contact with eyes, rinse immediately with plenty of water and seek medical advice; wear appropriate protective clothing, gloves and goggles or face - shield; in case of an accident or if you feel unwell, seek medical advice immediately.
Dangerous Goods Transport Number: UN 3261 8/PG 2.
WGK Germany: 3, indicating that it is highly toxic to aquatic organisms and may cause adverse effects on the water environment.
Storage Method: Sensitive to moisture, it should be stored in a desiccator, and the recommended storage temperature is usually +2°C to +8°C.