5-Chloro-2-methyl-4-isothiazolin-3-one

Product Details

CasNo： 26172-55-4

MF： C4H4ClNOS

Appearance： liquid

Delivery Time： 15 days

Packing： 200kg/drum

Purity： 99%

1. Basic Information

• English Name: 5-Chloro-2-methyl-4-isothiazolin-3-one; CMIT
• Chinese Name: 5 - 氯 - 2 - 甲基 - 4 - 异噻唑啉 - 3 - 酮；甲基氯异噻唑啉酮
• CAS Number: 26172-55-4
• Molecular Formula: C₄H₄ClNOS
• Molecular Weight: 149.59 g/mol
• Chemical Structure: A five-membered isothiazolinone ring with a chlorine atom at the 5-position, a methyl group at the 2-position, and a ketone group at the 3-position (key functional groups for biocidal activity).
• Common Forms: Typically supplied as a 20%–30% aqueous solution (to improve stability; pure CMIT is prone to polymerization at room temperature) or as a solid (rare, for specialized industrial use).

2. Physical and Chemical Properties

3. Key Performance Characteristics

1. Broad-Spectrum and Rapid Biocidal Activity
   CMIT exerts biocidal effects by disrupting the disulfide bonds in microbial proteins, irreversibly inhibiting cell metabolism. Its advantages include:

• Broad Antimicrobial Spectrum: Effectively kills gram-positive bacteria (e.g., Staphylococcus aureus), gram-negative bacteria (e.g., E. coli), fungi (e.g., Aspergillus niger), and algae (e.g., green algae), with minimum inhibitory concentrations (MIC) as low as 0.5–5 ppm (vs. 10–20 ppm for traditional biocides like formaldehyde releasers).
• Rapid Action: Achieves 99.9% bacterial kill within 5 minutes of contact (at recommended dosage), significantly faster than slow-acting biocides (e.g., benzisothiazolinone).

1. Good Compatibility and Formulation Adaptability

• Surfactant Compatibility: Fully miscible with anionic (e.g., SLES), cationic (e.g., cetrimonium chloride), and non-ionic (e.g., AEO-9) surfactants, with no precipitation or loss of activity in detergent or cosmetic formulations.
• Process Tolerance: Stable in low-temperature (0–40°C) water-based systems, suitable for cosmetics, latex paints, and industrial cooling water—no adverse impact on product texture, color, or viscosity.

1. Low Dosage and Cost-Effectiveness
   Due to its high biocidal efficiency, CMIT requires only 5–50 ppm in most applications (e.g., 10–15 ppm in cooling water, 8–15 ppm in rinse-off cosmetics), reducing overall biocide procurement costs by 30%–50% compared to conventional products.

4. Main Application Fields

1. Industrial Water Treatment (Largest Application)

2. Cosmetics and Personal Care

• Rinse-Off Products (shampoo, body wash, hand soap): Added at 8–15 ppm (compliant with global regulations) to prevent microbial spoilage during storage and use.
• Leave-On Products (moisturizers, serums): Used at ≤8 ppm (due to potential skin sensitization risks); often blended with methylisothiazolinone (MIT) in a 3:1 ratio to enhance efficacy and reduce irritation.

3. Coatings, Paints, and Adhesives

• Water-Based Latex Paints: Added at 20–40 ppm to inhibit mold growth on paint films (especially in humid environments) and prevent bacterial degradation of the paint matrix during storage.
• Industrial Adhesives: Used at 15–30 ppm to avoid microbial-induced viscosity changes and product deterioration.

5. Safety, Regulatory Compliance & Storage

1. Safety Information (Critical for Handling)

• Hazard Statements (per GHS):
  • H302 + H312: Harmful if swallowed or in contact with skin.
  • H314: Causes severe skin burns and eye damage.
  • H317: May cause an allergic skin reaction.
  • H331: Toxic if inhaled.
  • H400: Very toxic to aquatic life.
  • H410: Very toxic to aquatic life with long-lasting effects.
• Precautionary Statements:
  • P260: Do not breathe dust/fume/gas/mist/vapors/spray.
  • P273: Avoid release to the environment.
  • P280: Wear protective gloves/protective clothing/eye protection/face protection.
  • P301 + P312: If swallowed: Call a poison center/doctor if you feel unwell.
  • P305 + P351 + P338: If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

2. Regulatory Compliance

• Cosmetics: Complies with EU Regulation (EC) No 1223/2009 (maximum allowed concentration: 15 ppm in rinse-off products, 8 ppm in leave-on products) and US FDA 21 CFR §700.13.
• Industrial Use: Meets EU REACH registration, US EPA TSCA, and China GB/T 28174-2011 (standards for industrial biocides), ensuring legal use in global markets.

3. Packaging & Storage

• Packaging: 20 L HDPE plastic drums (for 20% aqueous solution), 1,000 L IBC totes (for bulk orders); sealed to prevent volatilization and contamination.
• Storage Conditions:
  • Store in a cool, dry, well-ventilated warehouse (temperature: 5–30°C); avoid direct sunlight and high temperatures.
  • Keep away from strong alkalis, reducing agents, and food/beverage products.
  • Shelf life: 6 months for 20% aqueous solution (unopened, under recommended storage conditions).