Product Details

CasNo： 604-68-2

MF： C16H22O11

Appearance： powder

Delivery Time： 15 days

Packing： 25kg/drum

Purity： 99%

Basic Information

Product Description

Product Name：Glucose pentaacetate

CAS No: 604-68-2

Form:powder

Product Application

1 Pharmaceutical Synthesis (Core Application)

α-Pentaacetyl glucose is a critical intermediate for nucleoside drugs, oligosaccharides, and glycoside compounds, primarily used for:

Nucleoside Drug Synthesis: In "glycosylation" steps for antiviral/anticancer nucleoside drugs (e.g., acyclovir, valacyclovir, capecitabine)—after deprotecting the C₁ acetyl group, it couples with bases (e.g., guanine, cytosine) to form nucleosidic bonds.

Oligosaccharide/Polysaccharide Synthesis: As a "glycosyl donor," it undergoes glycosylation reactions with another glycosyl acceptor (e.g., amino sugars, thio sugars) under Lewis acid catalysis (e.g., BF₃·Et₂O, SnCl₄) to construct glycosidic bonds (e.g., oligosaccharide chains in antibiotics, vaccines).

Chiral Drug Intermediates: Its α-stereochemistry transfers chiral information, enabling the synthesis of chiral drugs with specific configurations (e.g., cardiovascular drugs, central nervous system drugs).

2 Organic Synthesis (Chiral Building Block)

Chiral Synthon: Serves as a chiral source for asymmetric synthesis reactions (e.g., Aldol reaction, Michael addition) to build chiral molecules containing glucose structures.

Protecting Group Reagent: Temporarily protects glucose hydroxyl groups during complex molecule synthesis (avoids side reactions); active hydroxyl groups are restored after target reactions via ammonolysis or base hydrolysis.

3 Research and Laboratory Applications

Glycoscience Research: Studies glycosidic bond formation mechanisms and stereoselectivity of glycosylation (α vs β configuration).

Analytical Standard: Used as a standard for α-configured glucose derivatives in HPLC, GC, or NMR method calibration.

Packaging

25kg/drum

Storage

Store in a cool, dry, dark place (temperature ≤25°C, relative humidity ≤60%).