Monobenzone

Product Details

CasNo： 103-16-2

MF： C13H12O2

Appearance： powder

Delivery Time： 15 days

Packing： 25kg/bag

Purity： 99%

1. Basic Information

• CAS Number: 103-16-2
• Molecular Formula: C13​H12​O2​
• Molecular Weight: 200.23
• Appearance and Physical State: Typically amber crystalline powder
• Density: 1.26 g/cm³
• Melting Point: 119-120℃
• Boiling Point: 359.1℃ at 760 mmHg
• Solubility: Slightly soluble in water; highly soluble in ethanol, benzene, and diethyl ether; soluble in acetone and alkalis; practically insoluble in petroleum ether and hydrocarbons

2. Product Specifications

• Appearance: White or light gray crystalline powder
• Melting Point: 117.0-122.0℃
• Loss on Drying: ≤ 1.0%
• Residue on Ignition: ≤ 0.5%
• Related Impurities: Unknown impurity ≤ 0.50%; total impurities ≤ 1.0%
• Assay (HPLC, %): ≥ 99.0%

3. Performance Characteristics

• Significant Depigmenting Effect: It inhibits the activity of tyrosinase in melanocytes, blocks the conversion of tyrosine (a precursor of melanin) to dopaquinone, thereby reducing melanin production. It also accelerates the decomposition and metabolism of already formed melanin.
• Relatively Low Toxicity: Usually formulated into ointments or liniments, it has high safety under normal usage conditions.

4. Main Applications

• Pharmaceutical Field: As a skin depigmenting agent, it is applied topically to patients with widespread (affecting more than 50% of body surface area) primary vitiligo, which can cause permanent depigmentation of the normal skin surrounding vitiligo lesions. It can also be used to treat other skin conditions with excessive pigmentation, such as various chloasmas, age spots, and melanoma.

5. Usage Methods

• Dosage Form and Concentration: The common dosage form is cream, with a typical concentration of 20%.
• Frequency of Use: Generally recommended to be used 2-3 times a day.
• Duration of Treatment: Treatment usually lasts for 1-4 months. If the effect is unsatisfactory after 4 months, the medication should be discontinued and a doctor consulted.

6. Packaging and Storage

• Packaging: Aluminum foil bags (lined with polyethylene plastic bags), 25 kg per bag.
• Storage: Store in a cool and dry place; shelf life is 2 years.