Copper Gluconate

Product Details

CasNo： 527-09-3

MF： C12H22CuO14

Appearance： powder

Delivery Time： 15 days

Packing： 25kg/bag

Purity： 99%

1. Basic Information​

1.1 Chemical Formula​

The chemical formula of copper gluconate is ​

C12​H22​CuO14​

. It consists of 12 carbon atoms, 22 hydrogen atoms, 1 copper atom, and 14 oxygen atoms. This specific chemical structure gives it unique chemical and physical properties.​

1.2 Molecular Weight​

The molecular weight of copper gluconate is approximately 453.84 g/mol. This value is calculated based on the atomic weights of its constituent elements, which is crucial for accurately determining the amount of the compound in various applications, such as in pharmaceutical dosages and nutritional supplements.​

1.3 CAS Number​

The CAS (Chemical Abstracts Service) number of copper gluconate is 527 - 09 - 3. This unique identifier is used worldwide in scientific literature, chemical databases, and regulatory systems to precisely identify copper gluconate, ensuring consistent and accurate information exchange about the compound.​

1.4 Physical Properties​

Copper gluconate appears as a light blue to blue - green crystalline powder. It is odorless, which makes it suitable for use in a wide range of products where an absence of odor is desired, such as in food and pharmaceutical applications. It is stable in air, meaning it does not readily react with oxygen or other components in the atmosphere, ensuring a long - shelf life. It is highly soluble in water, with a solubility of approximately 47 g/100 mL at room temperature. However, it is only very slightly soluble in ethanol, which limits its use in alcohol - based formulations.​

2. Production Methods​

2.1 Reaction of Gluconic Acid with Copper Salts​

One common method is to react gluconic acid with copper salts, such as copper sulfate (​

CuSO4​

). In this process, gluconic acid, which can be obtained through the oxidation of glucose, reacts with copper sulfate in an aqueous solution. The chemical reaction can be represented as follows:​

2C6​H12​O7​+CuSO4​→C12​H22​CuO14​+H2​SO4​

​

​

The resulting solution is then processed through techniques like crystallization and purification to obtain pure copper gluconate.​

2.2 Reaction with Copper Oxide or Basic Copper Carbonate​

Copper gluconate can also be synthesized by reacting gluconic acid solution with copper oxide (​

CuO

) or basic copper carbonate (​

Cu2​(OH)2​CO3​

). For example, the reaction with copper oxide is as follows:​

2C6​H12​O7​+CuO→C12​H22​CuO14​+H2​O

​

​

This reaction occurs in an aqueous environment, and after the reaction is complete, the product is isolated and purified. Another approach is to use sodium gluconate and copper sulfate. First, the sodium - type strong - acidic cation - exchange resin is treated with a copper sulfate solution to convert it into a copper - type resin. Then, a sodium gluconate solution is passed through the copper - type resin column. The sodium ions in sodium gluconate are exchanged with copper ions on the resin, forming copper gluconate in the effluent. After collecting the effluent, it is concentrated and purified to obtain the final product.​

3. Pharmacological Effects​

Copper is an essential component of many important enzyme systems in the body. In the form of copper gluconate, it plays several crucial roles. It promotes the absorption and utilization of iron. Copper - containing enzymes are involved in the mobilization of iron from storage sites and its incorporation into hemoglobin, which is essential for oxygen transport in the blood. Additionally, copper is necessary for maintaining the normal function of the central nervous system. It is involved in the synthesis of neurotransmitters and the maintenance of the integrity of nerve cells. A deficiency of copper can lead to increased brittleness of various blood vessels and bones, atrophy of brain tissue, and may also cause melanin - loss disorders such as vitiligo and premature graying of hair.​

4. Indications​

4.1 Treatment of Copper - Deficiency - Related Diseases​

Copper gluconate can be used to treat diseases caused by copper deficiency, such as certain types of anemia. In cases where copper deficiency impairs iron metabolism and leads to anemia, supplementing with copper gluconate can help correct the iron - utilization problem and improve the anemia condition.​

4.2 Adjuvant Treatment for Parasitic Skin Infections​

It can be used as an adjuvant in the treatment of parasitic skin infections. Copper has antibacterial and antifungal properties, and in the form of copper gluconate, it may help in inhibiting the growth of certain parasites and pathogens on the skin, thereby assisting in the treatment of related skin infections.​

4.3 Potential Adjuvant Treatment for Osteoporosis and Hypertension​

Some studies suggest that copper gluconate may have a potential role in the adjuvant treatment of osteoporosis and hypertension. Copper is involved in the formation and maintenance of normal bone structure. Adequate copper levels may contribute to the proper function of enzymes related to bone metabolism. In the case of hypertension, copper - containing enzymes may be involved in regulating blood vessel tone and blood pressure, although more research is needed to fully understand and confirm these effects.​

5. Usage and Dosage​

For oral administration, the typical dosage for adults is 0.5 - 1.5 mg per day. For children, the dosage is usually 20 - 50 μg per day. When administering, it is often dissolved in 50 - 100 mL of physiological saline. However, the actual dosage should be carefully determined by a healthcare provider based on the patient's specific condition, age, weight, and other factors.​

6. Standards​

The production and quality control of copper gluconate follow the standard GB 1903.8 - 2015. This standard specifies requirements for aspects such as the appearance, identification, purity, heavy - metal content, and microbiological limits of copper gluconate, ensuring the safety and quality of the product for various applications.​

7. Application Areas​

7.1 Food Industry​

As a nutritional fortifier, copper gluconate can be added to a variety of food products, including beverages, dairy products, flour, and salt. According to the regulations of GB14880, in dairy products, the recommended dosage is 5.7 - 7.5 mg/kg, and in infant formula foods, the dosage is 7.5 - 10 mg/kg. Adding copper gluconate to these foods helps to meet the dietary copper requirements of consumers, especially in cases where the natural diet may be deficient in copper.​

7.2 Pharmaceutical Industry​

In the pharmaceutical industry, copper gluconate serves as a pharmaceutical intermediate. It can be used in the preparation of various copper - containing drugs or health supplements. These products are designed to address copper - deficiency conditions or to support overall health and well - being, taking advantage of the important physiological functions of copper in the body.​

8. Packaging and Storage​

8.1 Packaging​

Copper gluconate is typically packaged in plastic bags, which are then placed inside nylon bags or plastic - woven bags, with a net weight of 25 kg per package. Another common packaging option is in 25 - kg cardboard drums. These packaging materials are chosen to protect the product from moisture, light, and physical damage during storage and transportation.​

8.2 Storage​

It should be stored in a well - ventilated, dry, and dark warehouse. The product should be kept sealed to prevent moisture absorption, as exposure to moisture can affect its solubility and stability. Additionally, it should be stored away from light, as prolonged exposure to light can cause the product to decompose and turn black. Low - temperature storage is also recommended to maintain its quality over an extended period.​

9. Price​

The price of food - grade copper gluconate is approximately in the range of $46 - 50 per kilogram. However, the actual price may vary depending on factors such as the quantity purchased, market supply and demand, and the quality and reputation of the manufacturer. Larger - volume purchases may often be eligible for quantity discounts, which can lower the per - unit cost.​