Product Details
CasNo： 3632-91-5
MF： C12H22MgO14
Appearance： powder
Delivery Time： 15 days
Packing： 25kg/bag
Purity： 99%
1. Basic Information
- Chemical Formula: C12H22MgO14⋅2H2O (dihydrate form is common). For the anhydrous form, it is C12H22MgO14.
- Molecular Weight: 450.63 (dihydrate); 414.60 (anhydrous).
- Physical Properties: Appears as a white to off - white granular or powdered substance. It is odorless and has a bitter taste. It is highly soluble in water, with approximately 13g dissolving at room temperature. It is slightly soluble in ethanol and insoluble in ether.
2. Pharmacological Mechanisms
Magnesium gluconate dissociates into magnesium ions and gluconic acid in the body. Magnesium, as an essential element, participates in all energy metabolism processes within the body. It activates or catalyzes over 300 enzyme systems.
- Cardioprotective Effects: It can reduce the content of malondialdehyde in hypoxic - ischemic myocardial tissue, thereby decreasing the generation of oxygen - free radicals and playing an anti - lipid peroxidation role, protecting the hypoxic - ischemic myocardium.
- Vasorelaxant and Anti - thrombotic Effects: It has a significant muscle - relaxing effect, which can relieve coronary artery spasms, reduce the release of acetylcholine, maintain the balance of potassium and magnesium ions in the body, prevent platelet aggregation and the formation of coronary thrombi caused by magnesium deficiency, and exhibits calcium - antagonistic and membrane - stabilizing effects.
3. Medical Indications
In the medical field, magnesium gluconate is mainly used for the treatment of pregnancy - induced hypertension syndrome. By increasing the blood magnesium concentration, it helps to relieve symptoms associated with this condition, such as reducing vasospasm and stabilizing the physiological state of pregnant women.
4. Dosage Forms and Specifications
- Granules: For example, some products come in 3 - milligram granules.
- Oral Solution: A common specification is 1g/10ml, which is equivalent to 58.6mg of magnesium element per 10 - ml dose.
5. Usage and Dosage
Take granules as an example, they are usually taken orally. Dissolve each bag in about 100ml of warm water before taking. The general dosage is once in the morning and once in the evening, with 5 - 10g (1 - 2 bags) each time. However, the dosage should be adjusted according to the doctor's advice based on the patient's condition.
6. Adverse Reactions
In general, magnesium gluconate has a good safety profile. Some patients may experience diarrhea as an adverse reaction. Taking the drug after meals or dividing the dose can help alleviate such digestive symptoms.
7. Precautions
- Contraindications: Contraindicated in patients with renal insufficiency, hypotension, and respiratory depression. Also, it should not be used in patients with urine output < 100ml/4 hours and those with a respiratory rate < 16 breaths/min and absence of knee - jerk reflex.
- Medical Supervision: The drug should be used under the guidance of a doctor, and it should be avoided to be used in combination with central nervous system depressants.
- Monitoring: Before each dose, it is necessary to check the patient's respiratory rate and knee - jerk reflex. If the respiratory rate is < 16 breaths/min or the knee - jerk reflex disappears, the drug should be stopped immediately.
8. Application Areas
- Health Food and Nutrition Industry: Widely used in health foods, dairy products, beverages, flour products, special dietary foods, and infant foods as a magnesium - fortifying agent. Magnesium is an essential nutrient for the human body, involved in many physiological functions, and adding magnesium gluconate can enhance the nutritional value of these products.
- Pharmaceutical Industry: It can be used as a pharmaceutical intermediate and magnesium - strengthening agent in the pharmaceutical industry, playing an important role in the preparation of drugs related to magnesium supplementation and treatment of certain magnesium - deficiency - related diseases.
9. Production and Quality Control
Some manufacturers, such as Zhengzhou Ruipu, have standardized production processes and scientific and complete quality management systems. They have passed FSSC22000 system certification and their products are tested in national CNAS - accredited laboratories. They use unique sterilization techniques to strictly control the microbial index of products. Their magnesium gluconate products are divided into two series: regular products and refined products. The refined products are produced by special processes, with fine particles, better taste, and customizable physical and chemical indicators such as content and moisture to meet different customer needs.
10. Price
The price of food - grade magnesium gluconate is approximately $27 per kilogram, and it is usually packaged in 25 - kg units per piece. However, prices may vary depending on factors such as production costs, market demand, and product quality.
