Calcium gluconate

Product Details

CasNo： 299-28-5

MF： 2(C6H11O7).Ca

Appearance： powder

Delivery Time： 15 days

Packing： 25kg/bag

Purity： 99%

Basic Information

• Molecular Formula: C12​H22​O14​Ca (anhydrous); C12​H22​O14​Ca⋅H2​O (monohydrate)
• Molecular Weight: 430.37 (anhydrous); 448.40 (monohydrate)
• Properties: White crystalline particles or powder, odorless and tasteless, easily soluble in boiling water, slightly soluble in cold water, insoluble in organic solvents such as ethanol and ether.

Pharmacological Action

Calcium can maintain the normal excitability of nerves and muscles, promote the secretion of acetylcholine at nerve endings, promote the calcification and formation of bones and teeth, and also promote muscle contraction and nerve transmission. In addition, it can reduce the permeability of capillaries and play an anti - allergic role. High - concentration calcium ions have a competitive antagonistic effect with magnesium ions, and calcium ions can also form insoluble calcium fluoride with fluorides, which can be used for the treatment of magnesium and fluoride poisoning.

Indications

• Oral Preparations: Mainly used for the prevention and treatment of calcium deficiency diseases, such as osteoporosis, tetany, osteogenesis imperfecta, rickets, and can also be used for calcium supplementation in children, pregnant and lactating women, menopausal women and the elderly.
• Injection Preparations: Used for the treatment of calcium deficiency, acute hypocalcemia, alkalosis and tetany caused by hypoparathyroidism, and can also be used for allergic diseases, the treatment of magnesium poisoning, the treatment of fluoride poisoning and the application in cardiac resuscitation.

Usage and Dosage

• Calcium Gluconate Oral Solution: Oral, 10 - 20 ml at a time, 3 times a day.
• Calcium Gluconate Tablets: Oral, 0.5 g - 2 g at a time, 3 times a day.
• Calcium Gluconate Buccal Tablets: Buccal or chewable, 0.6 - 0.9 g at a time, 3 times a day.
• Calcium Gluconate Injection: Slowly inject after diluting with 10% glucose injection, not more than 5 ml per minute. For adults with hypocalcemia, 1 g at a time, repeat if necessary; for hypermagnesemia, 1 - 2 g at a time; for the treatment of fluoride poisoning, inject 1 g intravenously, repeat after 1 hour. For children with hypocalcemia, slowly inject 25 mg/kg (6.8 mg calcium) intravenously.

Adverse Reactions

Intravenous injection may cause systemic fever. Rapid intravenous injection can cause arrhythmia or even cardiac arrest, vomiting, and nausea. It can also cause hypercalcemia. Early symptoms may include constipation, drowsiness, persistent headache, loss of appetite, metallic taste in the mouth, and abnormal dry mouth. Late symptoms may include mental confusion, hypertension, photosensitivity of the eyes and skin, nausea, vomiting, and arrhythmia.

Precautions

Caution should be exercised in patients with heart and kidney insufficiency. It is 禁用 for those who are allergic to this product, and 慎用 for those with allergic constitution. This product is 禁用 when its properties change. Children must be under the supervision of adults. If other drugs are being used, consult a physician or pharmacist before using this product. When intravenous injection leaks out of blood vessels, it may cause local skin redness, rash and pain, and then peeling and tissue necrosis. Injection should be stopped immediately and corresponding treatment should be carried out. The use of this product is prohibited during the application of cardiac glycosides.