Hypromellose Acetate Succinate

Product Details

CasNo： 71138-97-1

MF： C10H22O9

Appearance： powder

Delivery Time： 15 days

Packing： 25kg/drum

Purity： 99%

Basic Information

Product Description

Product Name：Hypromellose Acetate Succinate

CAS No: 71138-97-1

Form: Powder

Product Application

Pharmaceutical Formulations

Enteric Coatings:​ HPMCAS is widely used for enteric coating of tablets, pellets, and capsules to protect acid-labile drugs or prevent gastric irritation. It forms continuous, tough, and glossy films that dissolve rapidly in intestinal pH.

Amorphous Solid Dispersions (ASD):​ As a carrier for poorly soluble drugs, HPMCAS enhances drug solubility and bioavailability by maintaining drugs in amorphous form. It is particularly effective for drugs with low aqueous solubility.

Hot-Melt Extrusion (HME):​ The low Tg and good thermoplastic properties make HPMCAS suitable for HME processes to prepare solid dispersions without organic solvents.

Taste Masking:​ Used to coat bitter drugs and mask unpleasant tastes in oral formulations.

Typical Usage Levels

Enteric coatings: 5-15% w/w in coating solutions

Solid dispersions: 5-80% w/w of final product weight

Hot-melt extrusion: typically 20-50% w/w with drug

Packaging

25Kg/Drum

Storage

Store in a tightly closed container at room temperature in a cool, dry place. Protect from moisture and light.