Hypromellose Acetate Succinate

Product Details

CasNo： 71138-97-1

MF： C10H22O9

Appearance： powder

Delivery Time： 15 days

Packing： 25kg/drum

Purity： 99%

• Basic Information
  • English Name: Hydroxypropyl Methylcellulose Acetate Succinate
  • CAS Number: 71138 - 97 - 1
  • Molecular Formula: C10​H22​O9​
  • Molecular Weight: 286.276
• Physical and Chemical Properties
  • Appearance: White to light yellow powder or granules, odorless.
  • Specific Gravity: 1.27 - 1.30
  • Solubility: Easily soluble in methanol, acetone, acetone/ethanol, acetone/methanol, methanol/dichloromethane, ethanol/dichloromethane (1:1 wt) mixture, and easily soluble in aqueous solutions with a pH higher than 5.0. Insoluble in water, acidic solutions, xylene and n - hexane.
  • Glass Transition Temperature: About 120℃, lower than that of hydroxypropyl methylcellulose (Tg value is about 170℃), so it is more likely to be softened and plasticized by heat to form a film.
  • Water Vapor Permeability: Low water vapor permeability, which can effectively block the penetration of moisture.
• Product Specifications: According to the different substitution degrees of acetyl and succinyl groups, it can be divided into three types: L, M and H. Each type can be further divided into two sub - specifications of coarse - particle size G and fine - particle size F. The coarse - particle size gives better fluidity, while the fine - particle size gives better mixing uniformity.
• Quality Index: The content is usually 99%, and the mesh number can reach 100. The viscosity is 2.4 - 3.6mPa·s, the free acetic acid succinate is ≤1.0%, the loss on drying is ≤5.0%, the ignition residue is ≤0.20%, and the heavy metal content is ≤0.001%.
• Usage
  • Enteric - Coating Material: It is a commonly used enteric - coating material with good film - forming property and good solubility in the upper part of the small intestine. It can be used for the enteric coating of tablets, capsules and granules.
  • Solid Dispersion Carrier: It can be used as a polymer carrier in solid dispersions to increase the solubility and bioavailability of poorly - soluble drugs and improve the drug absorption efficiency.
  • Preparation of Sustained - Release Formulations: It can be used alone or in combination with other soluble or insoluble binders to prepare pH - dependent drug - releasing granules with sustained - release function to control the drug release rate.
• Packaging and Storage
  • Packaging: Usually packed in cardboard drums, lined with double - layer polyethylene plastic bags, 25 kg/drum.
  • Storage: It should be stored in a normal - temperature and dry warehouse, and pay attention to moisture - proof, sun - proof and rain - proof.