Arbutin

Product Details

CasNo： 497-76-7

MF： C12H16O7

Appearance： powder

Delivery Time： 15 days

Packing： 25kg/bag

Purity： 99%

Here is the product details of Arbutin (CAS: 497-76-7):

• Basic Information
  • Chemical Name: 4 - Hydroxyphenyl β - D - glucopyranoside.
  • Molecular Formula: C₁₂H₁₆O₇.
  • Molecular Weight: 272.25.
  • Alias: β - Arbutin, p - Arbutin, Uvasol, Ursin, etc.
• Physical and Chemical Properties
  • Appearance: White solid or white needle - like crystals.
  • Solubility: Soluble in hot water, methanol, ethanol, propylene glycol and glycerol aqueous solution, insoluble in ether, chloroform, petroleum ether and other solvents.
  • Melting Point: 198 - 201℃.
  • Density: 1.556g/cm³.
  • Refractive Index: 1.65.
  • Stability: Stable, hygroscopic, should be stored under dry nitrogen.
• Extraction and Synthesis
  • Extraction: It can be extracted from various plants such as Arctostaphylos uva - ursi, Vaccinium bracteatum, and Pyrus leaves. Through separation and purification methods such as organic solvent extraction and column chromatography, arbutin can be obtained.
  • Synthesis: It can be synthesized by chemical methods. It can also be obtained by the enzyme - conversion method using hydroquinone and glucose under the catalysis of β - glycosidase.
• Pharmacological Effects
  • Inhibiting Melanin: It can inhibit the activity of tyrosinase, block the synthesis of dopa and dopaquinone, curb the growth of melanin, reduce melanin deposition, and remove age spots and freckles.
  • Analgesic, Anti - inflammatory and Antibacterial: It can be used for anti - inflammation and anti - ulcer, and can inhibit insulin degradation. Hydroquinone produced by oral hydrolysis has a bactericidal effect, which can be used to treat urinary tract infections and intestinal anti - inflammation.
  • Antitussive, Expectorant and Anti - Asthmatic: It has certain antitussive, expectorant and anti - asthmatic effects. It can increase tracheal secretion, prolong the latent period of ammonia - water induced cough, reduce the number of coughs, and increase the excretion of phenol red in the trachea.
• Application Fields
  • Cosmetics: As an effective competitive inhibitor of tyrosinase, it is commonly used as a whitening raw material in high - end cosmetics. It can reduce melanin production and achieve the effect of whitening skin.
  • Pharmaceuticals: It has a low - toxicity antitussive effect and has a high selectivity for the central nervous system. It can be used as a urinary disinfectant, a new type of burn medicine, a cryoprotectant in cartilage bone transplantation, a decolorizing agent, a raw material for intestinal anti - inflammatory drugs, etc. It can also be used to treat tracheitis, infectious urinary system diseases, allergies, skin diseases and inflammatory diseases.
• Safety Considerations: The Scientific Committee on Consumer Safety of the European Union stipulates that the maximum safe use concentration of β - arbutin in facial creams is 7%. When the addition amount of β - arbutin in cosmetics is greater than 3%, it will significantly inhibit or damage cell growth, resulting in cytotoxicity.